Researchers examined eight familial melanoma genes in nearly 697,000 people across two datasets. Disease-associated variants exceeded a 2.5% prevalence threshold among people with multiple melanomas or a first melanoma before age 40.
Read story: Genetic risk in melanoma: what age at diagnosis and multiple tumours reveal ↗In the RECOVER-VITAL analysis of 959 adults, researchers evaluated fifteen or twenty-five days of nirmatrelvir–ritonavir. At day ninety, neither regimen significantly improved…
Read story: Extended antiviral treatment showed no benefit in long COVID trial ↗The SenCat project compared more than 30 senescence conditions across 14 human cell types. RNA and protein measurements revealed no single marker…
Read story: No single signature identifies every senescent cell ↗In newborn mice, C. difficile colonization changed intestinal inflammatory and repair responses without obvious illness. Some cellular changes persisted into adulthood. Tissue…
Read story: A symptom-free gut bacterium may leave lasting developmental changes ↗Researchers evaluated cell-senescence protein signatures in two longitudinal cohorts: 1,275 BLSA participants and 997 InCHIANTI participants. Signatures from different cell types showed…
Read story: Blood protein patterns track different dimensions of ageing ↗Researchers compared postmortem brain tissue from ten people with Alzheimer’s disease and ten without it. Measuring DNA folding and gene activity together…
Read story: Alzheimer’s research looks beyond DNA’s letters to how it folds ↗Researchers examined 99 lymph-node sections from 51 donors aged 18–86, covering roughly 20 million cells. The location of senescence markers shifted with…
Read story: Mapping immune ageing: cell patterns shift in lymph nodes ↗Some antibodies from people with long COVID targeted nervous-system proteins. Transferring patient-derived IgG into mice produced fatigue-like behaviour, balance problems, heightened pain…
Read story: Autoantibodies offer a clue to neurological long COVID ↗Combining more than ten million cellular and spatial gene-expression profiles, researchers identified nine recurring tumour-neighbourhood patterns. Patterns recovered from blood cell-free DNA…
Read story: Can blood reveal the cellular neighbourhood around a tumour? ↗Researchers tested human antibodies that bind alpha-gal in laboratory experiments. Some blocked allergic patients’ IgE from binding selected allergens; particular antibody formats…
Read story: Antibodies that block the immune response in meat allergy ↗A randomized trial of 830 children with severe early childhood caries evaluated silver diamine fluoride. At six months, 54% of treated lesions…
Read story: Liquid dental treatment stopped progression in some childhood cavities ↗Data from roughly 30,000 children attending California pediatric clinics showed that a brief measure of unpredictability contributed information about mental health problems…
Read story: A question in children’s mental health: how predictable is daily life? ↗Across 183 samples from 21 North Carolina treatment plants, researchers detected DNA from 184 plant and 116 animal food groups. Patterns in…
Read story: Can DNA in wastewater reveal what a community eats? ↗Researchers used accumulated genetic changes to trace cell origins in tissues from 20 older people. They identified bone marrow-derived cells in the…
Read story: Bone marrow-derived immune cells leave traces in the ageing brain ↗Researchers analysed smoking, alcohol, diet, activity and body mass index in 287,745 UK Biobank participants. Higher healthy-lifestyle scores were associated with lower…
Read story: Lifestyle and cancer risk examined in 287,000 people ↗Laboratory experiments found that antibiotic stress promoted protein transfer inside small bacterial vesicles. In E. coli, receiving these proteins increased persistence during…
Read story: Bacteria share proteins to survive antibiotic stress ↗In preclinical lung cancer models, researchers linked tumor production of the signaling molecule PGE2 to sensory nerves involved in cancer-associated wasting. A…
Read story: Cancer wasting may involve more than eating less: clues from animal models ↗Human datasets linked greater physical activity with a lower prevalence of some forms of clonal blood-cell production. In mice, uninterrupted sleep and…
Read story: Sleep and exercise may affect blood-cell clones differently by mutation ↗
